Mechanism
Acetyl-L-carnitine is an acetylated derivative of the amino acid L-carnitine; it possesses both superior bioavailability and unique properties over the basal L-carnitine molecule. Acetyl-L-carnitine exhibits an array of properties from increased stamina to the donation of its acetyl molecule in the brain to create acetyl-choline a powerful neurotransmitter indicated in memory function and learning. Recent research has also suggested acetyl-L-carnitine may be a powerful life-extension drug revitalizing mitochondrial energy production via oxidative phosphorylation resulting in increased ATP levels (a key energy source in the body)
Uses
So what can Acetyl-L-carnitine do for you?
•Increases average life-span and reinvigorates seniors.
•Increases brain acetyl-choline and thus improves memory and learning
•Has been shown to be more effective than tamoxifen in correcting penile curvature.
•Improves exercise endurance
•May aid in weight-loss.
•Neuroprotective
•Increases sperm mobility.
•May boost testosterone levels
• May alleviate depression
Issues
The process of oxidative phosphorylation produces a number of free radicals and can create cellular mutation. In studies: acetyl-L-cartinine failed to increase the average life-span of rats unless coupled with the powerful anti-oxidant and free radical scavenger ALA (alpha lipoic acid) I strongly recommend this synergy. L-carnitine is produced by the kidneys and patients suffering renal conditions are advised to take this supplement (always check with your GP)
Dosage
The dose for acetyl-l-carnitine is goal specific however, a starting dose of 500mg three times daily is recommended; to accompany this 125mg of ALA should also be taken three times daily.
Experiences
The acetyl-l-carnitine/ALA combination is one that I come back to time and time again and it always surprises me just how potent it is. My energy levels go through the roof, my libido increases; I feel content and enthusiastic. Its nootropic effect seems subtle, but, with the myriad of other benefits, who cares. A final note: I suffer from stomach problems and ALA exaggerates these if I don’t take it with sufficient quantities of water.