Mechanism
Modafinil is an analeptic proven to increase daytime wakefulness, be effective in the treatment of narcolepsy and shift-work sleep disorder. Its plethora of chemical mechanisms in vivo are not fully understood. Like other stimulants modafinil increases levels of the monoamines dopamine and norepinephrine but also elevates hypothalamic histamine levels. Modafini also activates glutamatergric circuits while inhibiting GABAergic neurotransmissions.But… is it really a nootropic?
Uses
•Dopamine activity may increase concentration and focus.
•May decrease appetite and be useful in weight loss
•Reduces fatigue without excessive CNS stimulation unlike caffeine.
•Powerful yet non-addicting stimulant.
•Improves mood
•Improves memory
Issues
Modafinil’s long-term usage profile has not been established and hence hepatic and renal long-term toxicity is currently unknown. Modafinil has been labeled as a possible cause of the rare dermatological condition: Steven Johnson’s Syndrome; although no more than 6 cases – not all concretely linked to modafinil use alone – have been reported during its life-time.
Dosage
The recommended dosage for modafinil is a single 200mg tablet taken in the morning, however it is not unheard of for US patients to be prescribed up to 400mg of modafinil daily. In trials modafinil shows little superior efficacy at doses above 200mg.
Experiences
It’s been a week since I began taking modafinil. I began with a preliminary dose of 150mg which I found to be over-stimulating and I have now found a comfortable dose regime of 50mg twice daily. Although subtle – modafinil lifts the shroud of my fatigue, improves my mood and increases my drive and enthusiasm. All in all this drug is a very mild yet expensive stimulant offering a subtle, yet appreciable effects profile and I would recommend it for anyone with cash to burn. Beware of the stinky urine! 🙂